BOTULINUM TOXIN FROWN LINE

Dernière mise à jour : 17 July 2026

What is a frown line ?

Frown lines are vertical wrinkles between the eyebrows in the glabella. They primarily result from repeated contractions of the corrugator and procerus muscles, progressively compounded by age-related loss of collagen, elastin and hyaluronic acid. Over time, they become visible even at rest and can give the face a severe, worried or tired appearance. In aesthetic medicine, botulinum toxin is the reference treatment for frown lines.
This technique temporarily relaxes the muscles responsible. When wrinkles are already pronounced at rest, hyaluronic acid or Skinbooster injections or laser sessions may be combined with it.

Key facts about frown lines

  • Located between the eyebrows (glabella)
  • Also called glabellar lines
  • Primarily associated with repeated muscle contractions
  • Gradually become permanent with age
  • Often create a severe or worried appearance
  • Botulinum toxin is the standard treatment
  • Hyaluronic acid injections may complement treatment when the wrinkle is indented at rest
  • Session length : 10 to 20 minutes
  • Pain : 1 to 2/10
  • Anaesthesia : none
  • Botulinum toxin result : 3 to 7 days
  • Optimal result : 10 to 15 days
  • Duration of results : 4 to 6 months
  • Social downtime : none
  • Return to work : immediate
  • Return to sport : 48 hours
  • Price : 250-300 CHF (one area), 600-650 CHF (3 areas)

Evidence from clinical studies on frown lines

  • A study published in Plastic and Reconstructive Surgery shows that botulinum toxin significantly reduces glabellar lines (frown lines), both at rest and during muscle contraction, with high patient satisfaction.
  • A review published in Clinical, Cosmetic and Investigational Dermatology confirms that botulinum toxin is the reference treatment for frown lines because of its effectiveness, safety and excellent tolerability.
  • Data from the National Institutes of Health (NIH) show that frown lines result from repeated corrugator and procerus muscle contractions combined with progressive ageing of collagen and supporting tissues.
  • The American Academy of Dermatology (AAD) recommends botulinum toxin as first-line treatment for frown lines, naturally smoothing expression lines while preserving facial movement.
Contents
  1. Types of frown line
  2. What causes frown lines ?
  3. Severity stages of frown lines
  4. How can frown lines be removed without injections ?
  5. How can you get rid of frown lines ?
  6. How can frown lines be removed ?Botulinum toxin injections for frown lines
  7. How botulinum toxin injections for frown lines are performed
  8. Contraindications to botulinum toxin injections for frown lines
  9. How can frown lines be removed ? Filling frown lines with hyaluronic acid
  10. Before / after results of botulinum toxin injections for frown lines
  11. What is the price of an injection for frown lines ?
  12. Frequently asked questions about frown lines
  13. Articles about frown lines

Types of frown line

Several muscles are involved when frowning — particularly the frontalis, orbicularis oculi, corrugator and procerus. Their activation varies between individuals according to anatomy and expression habits. These muscle dynamics determine five types of frown line, each with a specific shape and depth.
This classification is not merely descriptive : it guides treatment strategy. Injection technique must suit muscle contraction patterns to achieve natural, harmonious results while preserving eye expression. Precise assessment of movements during consultation personalises treatment and optimises effectiveness.

Frown line

Omega-type
frown line

Frown line

Inverted omega-type
frown line

Frown line

Frown line
V type

Frown line

Frown line
U type

Frown line

Converging arrow-type
frown line

Frown line

What causes
frown lines ?

The main causes of frown lines are :

  • Repeated muscle contractions : frown lines primarily result from corrugator muscle activity. These muscles lie at the inner eyebrows. They allow us to frown by lowering the inner brow.
    They develop fairly quickly because facial expressions repeatedly engage them, explaining wrinkles even in very young patients.
    Wrinkles first appear during expressions, then become permanent once the skin has creased.
  • Ageing : skin loses elasticity and its ability to fully relax after muscle contraction.
  • Genetic factors : genetic predisposition may influence wrinkle depth and how early it develops.
  • Sun exposure : UV damage accelerates skin ageing and wrinkle formation.
  • Smoking : smoking reduces skin blood circulation, accelerating ageing.

Severity stages of frown lines

Four severity stages of frown lines are described for treatment purposes.

Stage 1 : mild wrinkles

Initially, frown lines appear as fine lines visible only when the corrugator muscles contract during frowning. Skin still retains good elasticity and fine lines disappear at rest.

Stage 2 : moderate wrinkles

At this stage, wrinkles are visible even at rest. They begin becoming permanent as collagen and elastin production declines. Skin starts losing firmness and wrinkles become more pronounced.

Stage 3 : deep wrinkles

Frown lines become deep and permanently visible even when the face is relaxed. Skin elasticity and volume loss is significant and wrinkles more pronounced.

Stage 4 : very deep wrinkles

At an advanced stage, frown lines are very deep and well defined, often accompanied by skin folds. Skin has lost much of its elasticity and volume. Wrinkles give the face a severe, constantly worried appearance.

At early stages, botulinum toxin injection removes the wrinkle.
At more advanced stages, if complete removal is desired, hyaluronic acid injections should be performed one month after botulinum toxin.
The muscle responsible is powerful, and botulinum toxin treatment of deep or very deep wrinkles is possible, but results last 3-4 months. Hence the importance of treating this wrinkle when it first appears.

How can frown lines be removed
without injections ?

Among natural ways to soften this wrinkle, facial exercises offer a non-invasive approach beneficial to skin health. Specific exercises may help reduce frown lines and refresh a tired face.
Facial exercises complement injections, but cannot prevent or treat frown lines without combining them with injections.

Facial exercises : a natural solution for frown lines

Facial exercises involve movements intended to strengthen and tone facial muscles. They may help smooth wrinkles and improve skin firmness. Several targeted movements for frown lines can be incorporated into a daily routine.
The most common exercise places three fingers at the inner eyebrow and stretches it outwards while frowning.

Frown line

How can you get rid of frown lines ?

There are many options to prevent and treat frown lines and keep skin smooth and youthful.
Botulinum toxin injection is the most widely used and effective treatment.
In certain indications, hyaluronic acid injections may be combined with it.

Frown line

How can frown lines be removed ?
Botulinum toxin injections
for frown lines

An injection of botulinum toxin blocks corrugator muscle contraction. The patient can no longer frown, but inability to perform this movement does not create a frozen appearance. Inability to raise the eyebrows is what freezes the face.
For some people (particularly certain artistic professions), retaining the ability to frown is important, so partial blocking is possible.
Assessment at rest and during frowning precedes treatment.
Crow's feet injections are often combined to fully open the eye area without changing eyebrow shape.

Poorly performed frown line injection

A poorly performed injection here causes :

  • Drooping eyelid (ptosis) caused by product spreading to the upper eyelid elevator muscle.
  • Drooping eyebrow with inability to raise the eyebrows (creating a frozen appearance), caused by injection too high affecting the frontalis muscle.

How botulinum toxin injections for frown lines are performed

Botulinum toxin treatment for frown lines is a medical procedure performed at the practice. Very small quantities are injected into the corrugator and procerus muscles responsible for frowning and vertical wrinkles between the eyes.

Before the session

Consultation assesses upper facial dynamics, muscle contraction intensity and wrinkle depth. Dr Romano checks for contraindications, explains botulinum toxin's mechanism and defines a treatment plan suited to patient anatomy to preserve natural expressions.

During the session

After skin disinfection, two injections are performed with a very fine needle into the targeted muscles. The procedure generally lasts between 10 and 15 minutes and requires no anaesthesia. Doses are precisely adapted to reduce contraction without freezing the face.

After the session

Daily activities can resume immediately. Avoid massaging the treated area during the first hours, as well as intense exercise, sauna, steam rooms and prolonged head-down positions on treatment day.

Contraindications to botulinum toxin injections for frown lines

Botulinum toxin injections are preceded by a medical consultation to exclude contraindications and ensure safety.
The main contraindications are :

  • Pregnancy and breastfeeding.
  • Known allergy to botulinum toxin or any product excipient.
  • Infection or inflammation in the treatment area.
  • Neuromuscular diseases, particularly myasthenia gravis, Lambert-Eaton syndrome or amyotrophic lateral sclerosis.
  • Certain medicines that may enhance botulinum toxin's effects, particularly some aminoglycoside antibiotics, following medical assessment.
  • Swallowing or muscle function disorders when incompatible with treatment.

How can frown lines be removed ? Filling frown lines with hyaluronic acid

Sometimes botulinum toxin alone cannot correct a frown line. Filling with hyaluronic acid becomes relevant, particularly when the patient cannot receive botulinum toxin (contraindications, refusal…) or when the wrinkle has formed a genuine skin crease. In the latter case, hyaluronic acid injection is generally performed about a month after botulinum toxin for optimal results.
An experienced doctor must use a cannula, because this delicate area carries a risk of necrosis or visible product irregularities. Product selection depends on wrinkle depth : a volumiser is preferred for a deep wrinkle, while a Skinbooster-type acid suits a very superficial crease.

Frown line

Before / after results of botulinum toxin injections for frown lines

Frown line treatment softens expression and removes the severe or displeased appearance it may create. The eye area looks immediately more rested and rejuvenated.
Botulinum toxin effects begin from the second day after injection and become fully visible after about a week. They last five to six months on average. Follow-up, potentially with a touch-up, is scheduled one to three weeks after the session. Recovery is generally straightforward, with occasional slight swelling for a few minutes and mild headaches that may persist for up to five days.
Hyaluronic acid injection results are immediate and last one year.
After-effects are minimal, allowing immediate resumption of daily activities.

What is the price of an injection for frown lines ?

In Geneva, botulinum toxin injection for frown lines costs 300 CHF for women and 350 CHF for men, 450 CHF for two areas in women and 500 CHF in men, and 600 CHF for three areas in women and 650 CHF in men. If complementary hyaluronic acid injection is needed, it costs 600 CHF per syringe.
The treatment plan is personalised. At the initial consultation, Dr Romano and the patient define the solution best suited to individual needs for a natural, harmonious result.
Whether preventing a frown line or softening an established wrinkle, the goal is a relaxed, open expression without freezing the face.
All procedures take place in a medical environment using certified products.
Botulinum toxin injection prices for frown lines in Geneva vary according to the number of areas (frown lines count as one) and sex (because muscle strength differs).

For women 

  • 1 area (frown line) : 300 CHF
  • 2 areas : 450 CHF
  • 3 areas : 600 CHF


For men 

  • 1 area (frown line) : 350 CHF
  • 2 areas : 500 CHF
  • 3 areas : 650 CHF

If the wrinkle is too pronounced to disappear completely with botulinum toxin, complementary hyaluronic acid injection may be offered for optimal results. This injection costs 600 CHF.

Frequently asked questions about frown lines

How can frown lines be prevented ?

Prevention is key to reducing frown lines. Effective advice.

  • Sunglasses : to avoid squinting in sunlight.
  • Apply moisturisers to maintain good skin elasticity.
  • Sun protection.
  • Stop smoking : smoking accelerates skin ageing.
  • Skincare : use products containing antioxidants and anti-ageing ingredients.

Which oil for frown lines ?

Certain essential and plant oils may help reduce frown lines through hydrating and regenerative properties.

  • Rosehip oil : rich in essential fatty acids and vitamin A, it helps regenerate skin and reduce wrinkles.
  • Argan oil : known for hydrating and antioxidant properties, it helps improve skin elasticity.
  • Frankincense oil : has anti-ageing properties and may help smooth wrinkles.

Which cream for frown lines ?

For frown line care, creams containing the following ingredients are recommended :

  • Retinol : stimulates collagen production and accelerates cell renewal.
  • Hyaluronic acid : deeply hydrates skin and fills wrinkles.
  • Peptides : help strengthen skin structure and stimulate collagen and elastin production.
  • Antioxidants : such as vitamins C and E, to protect against free radical damage.

Does Gua Sha work on frown lines ?

Gua Sha is a massage technique using a specific tool to gently scrape the skin, traditionally used in Chinese medicine. It aims to improve blood circulation and encourage lymphatic drainage.
Regular Gua Sha use could potentially benefit frown lines.
Results vary between individuals and Gua Sha does not provide the same results as medical treatments.

At what age do frown lines appear ?

Frown lines may begin in the late twenties or early thirties, but generally become more pronounced with age, particularly after forty. Genetics, sun exposure and smoking influence onset.

When will frown line filling results appear ?

Botulinum toxin injection results for frown lines appear three to five days afterwards, with maximum effect after one week. Effects generally last between three and six months, and maintenance sessions are needed to preserve results.

Are botulinum toxin injections for frown lines painful ?

Botulinum toxin injections are generally well tolerated and only mildly uncomfortable. The sensation is often compared to a slight insect bite. A topical anaesthetic may be applied beforehand.

Are anti-wrinkle creams effective for reducing frown lines ?

Anti-wrinkle creams improve skin appearance by increasing hydration and stimulating collagen and elastin production. However, they cannot relax the muscles responsible for frown lines. For significant results, creams must be combined with botulinum toxin or hyaluronic acid injections.

What are the benefits of facial exercises for frown lines ?

Facial exercises strengthen muscles, improve blood circulation and reduce wrinkle appearance. For optimal results, combine them with good hydration and appropriate skincare.

Where are frown lines located ?

Frown lines are between the eyebrows on the forehead. They are often vertical.

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