BOTULINUM TOXIN FROWN LINE

What is the frown line ?

Frown lines are the vertical wrinkles located between the eyebrows, in the glabellar region. They are primarily caused by repeated contractions of the corrugator and procerus muscles, combined with the progressive decline in collagen, elastin, and hyaluronic acid associated with skin ageing. Over time, these wrinkles become visible even at rest and can give the face a stern, worried, or tired appearance. In aesthetic medicine, botulinum toxin is the reference treatment for frown lines.
This technique temporarily relaxes the muscles responsible for their formation. When the wrinkles are already visible at rest, hyaluronic acid injections, Skinboosters, or laser treatments may also be combined.

Key data on frown lines

  • Located between the eyebrows (glabella)
  • Also known as glabellar lines
  • Primarily caused by repeated muscle contractions
  • Gradually become permanent with age
  • Often give the face a stern or worried appearance
  • Botulinum toxin is the reference treatment
  • Hyaluronic acid injections can complement the treatment if the wrinkle remains visible at rest
  • Treatment time : 10 to 20 minutes
  • Pain : 1 to 2/10
  • Anesthesia : none
  • Botulinum toxin results : 3 to 7 days
  • Optimal result : 10 to 15 days
  • Duration of results : 4 to 6 months
  • Social downtime : none
  • Return to work : immediate
  • Return to sports activities : 48 hours
  • Price : CHF 250–300 (1 treatment area), CHF 600–650 (3 treatment areas)

Clinical study data on frown lines

  • A study published in Plastic and Reconstructive Surgery showed that botulinum toxin significantly reduces glabellar lines (frown lines), both at rest and during muscle contraction, with a high level of patient satisfaction.
  • A review published in Clinical, Cosmetic and Investigational Dermatology confirms that botulinum toxin is the reference treatment for frown lines because of its proven efficacy, safety, and excellent tolerability profile.
  • The National Institutes of Health (NIH) data show that frown lines result from repeated contractions of the corrugator and procerus muscles, combined with the progressive ageing of collagen and the supporting tissues.
  • The American Academy of Dermatology (AAD) recommends botulinum toxin as the first-line treatment for frown lines, providing a natural smoothing of expression lines while preserving normal facial expressions.

Contents

Types of frown lines

When we frown, several muscles are involved — notably the frontalis, orbicularis oculi, corrugator, and procerus. Their activation varies from person to person depending on facial structure and habitual expressions. This muscular dynamic determines the appearance of five types of frown lines, each with its own specific shape and depth.
This classification is not merely descriptive : it guides the therapeutic strategy. Indeed, the injection technique must be adapted to the type of muscle contraction in order to achieve a natural and harmonious result while preserving the expressiveness of the eyes. A precise analysis of the patient’s movements during the consultation thus makes it possible to personalize the treatment and optimize its effectiveness.

photo ride du lion type omega

Frown line type
omega

photo inverted omega lion wrinkle

Frown line type
inverted omega

photo ride du lion type V

Frown line
type V

photo ride du lion type U

Frown line
type U

photo of lion wrinkle converging arrows

Frown line type
converging arrows

photo causes ride du lion

What causes the frown line ?

The main causes of the frown line include :

  • Repeated muscle contractions : the frown line is mainly caused by the action of the corrugator muscles. The corrugator muscles are located at the inner part of the eyebrow. They allow us to frown, acting as depressors of the inner brow.
    These muscles develop quite rapidly because they are engaged during facial expressions, which explains the appearance of the line even in very young patients.
    Wrinkles first appear during expressions, then become permanent once the skin has creased.
  • Aging : with age, the skin loses its elasticity and its ability to fully relax after a muscle contraction.
  • Genetic factors : genetic predisposition can influence the depth and the early appearance of this wrinkle.
  • Sun exposure : damage caused by UV rays accelerates skin aging and wrinkle formation.
  • Smoking : smoking reduces blood circulation in the skin, accelerating skin aging.

Severity stages of the frown line

For therapeutic purposes, the frown line is classified into four severity stages .

Stage 1 : mild lines

At this early stage, frown lines appear as fine lines only when the corrugator muscles contract during frowning. The skin still has good elasticity, and the lines disappear at rest.

Stage 2 : moderate wrinkles

At this stage, wrinkles are visible even at rest. They begin to set in permanently due to the decrease in collagen and elastin production. The skin starts to lose its firmness and the wrinkles become more pronounced.

Stage 3 : deep lines

Frown lines become deep and permanently visible, even when the face is relaxed. The loss of skin elasticity and volume is significant, and the wrinkles are more pronounced.

Stage 4 : very deep lines

In the advanced stage, frown lines are very deep and well defined, often accompanied by skin folds. The skin has lost most of its elasticity and volume. The wrinkles give the face a stern and constantly concerned expression.

At early stages, botulinum toxin injection makes the wrinkle disappear.
At more advanced stages, if the patient wishes for complete wrinkle removal, hyaluronic acid injections should be performed one month after the botulinum toxin injection.
The muscle responsible for the frown line is a powerful one ; its treatment with botulinum toxin at the deep or very deep stage is possible, but the result will last 3–4 months. Hence the importance of treating this type of wrinkle as soon as it appears.

photo natural lion wrinkle treatment

How to erase the frown line without injections ?

Among the natural methods to reduce this wrinkle, facial gymnastics stands out for its non-invasive approach and its benefits for skin health. Specific facial exercises can help reduce the frown line and refresh the face.
Facial gymnastics is a complement to injections, but this technique cannot prevent or treat the frown line if it is not combined with injections.

Facial gymnastics : a natural solution for frown lines

Facial gymnastics consists of a series of exercises aimed at strengthening and toning the facial muscles. These exercises can help smooth wrinkles and improve the firmness of the skin. For the frown line, several targeted movements can be incorporated into your daily routine.
The most common exercise involves placing three fingers on the inner part of the eyebrow and stretching it outward while frowning.

How do you get rid of frown lines ?

There are many options to prevent and treat the frown line in order to keep the skin smooth and youthful.
The most commonly used and most effective treatment is the injection of botulinum toxin.
It is also possible, in certain cases, to combine it with hyaluronic acid injections.

photo of lion wrinkle treatment by botox injection

How to remove frown lines ? Botulinum toxin injections for the glabellar lines

The injection of botulinum toxin blocks the contraction of the corrugator muscles. The patient will no longer be able to frown, but this inability does not result in a frozen expression. It is the inability to raise the eyebrows that makes the face look frozen.
For some people (particularly in certain artistic professions), it is important to retain the ability to frown ; in this case, a partial blockage is possible.
An analysis at rest and during frowning precedes the treatment.
It is often combined with the injection of crow’s feet wrinkles to achieve a fully open look and avoid altering the eyebrow shape.

Failed frown line injection

A failed injection in this area may cause :

  • Eyelid drooping (ptosis), caused by diffusion of the product to the levator muscle of the upper eyelid.
  • Brow drooping with inability to raise the eyebrows (creating a stiff look), caused by injection too high into the frontalis muscle.

Botulinum toxin injections for the treatment of frown lines

Treatment of frown lines with botulinum toxin is a medical procedure performed in the clinic. It consists of injecting very small amounts of the product into the corrugator muscles and the procerus muscle, which are responsible for frowning and the formation of vertical wrinkles between the eyes.

Before the session

La consultation permet d’analyser la dynamique du haut du visage, l’intensité de la contraction musculaire et la profondeur de la ride du lion. Le docteur Romano recherche les éventuelles contre-indications, explique le mécanisme d’action de la toxine botulique et définit un plan de traitement adapté à la morphologie du patient afin de préserver des expressions naturelles.

During the procedure

After disinfecting the skin, two injections are performed using a very fine needle into the targeted muscles. The procedure generally takes between 10 and 15 minutes and does not require anaesthesia. The doses are carefully tailored to reduce muscle contraction without freezing the facial expressions.

After the session

Daily activities can be resumed immediately. It is recommended to avoid massaging the treated area during the first few hours, as well as intense physical exercise, saunas, steam rooms, and prolonged positions with the head bent forward on the day of treatment.

Contraindications to botulinum toxin injections for frown lines

Botulinum toxin injections are preceded by a medical consultation to confirm the absence of contraindications and ensure the safety of the treatment.
The main contraindications are :

  • Pregnancy and breastfeeding.
  • Known allergy to botulinum toxin or to any of the product's excipients.
  • Infection or inflammation at the treatment site.
  • Neuromuscular disorders, including myasthenia gravis, Lambert-Eaton syndrome, and amyotrophic lateral sclerosis.
  • Treatment with certain medications that may potentiate the effects of botulinum toxin, particularly certain antibiotics from the aminoglycoside class, following medical evaluation.
  • Swallowing disorders or muscle function disorders that are incompatible with the treatment.
photo filler lion wrinkle with hyaluronic acid

How to make the frown line disappear ? Frown line filling with hyaluronic acid

In some cases, botulinum toxin alone is not enough to correct the frown line. Filling with hyaluronic acid then becomes a relevant option, particularly when the patient cannot receive botulinum toxin (contraindications, refusal, etc.) or when the wrinkle has already created a true skin break. In the latter case, the hyaluronic acid injection is usually performed about one month after the botulinum toxin treatment to achieve an optimal result.
This procedure must be performed with a cannula and by an experienced doctor, as the area is delicate and carries a risk of necrosis or product visibility in the form of small irregularities. The choice of hyaluronic acid depends on the depth of the wrinkle : a volumizing product will be preferred for a deep wrinkle, while a Skinbooster-type acid will be indicated for a very superficial break.

Before and after results of botulinum toxin injections for frown lines

The treatment of the frown line helps soften the expression and erase the stern or worried look it can give. The eyes appear immediately more relaxed and rejuvenated.
The effects of botulinum toxin begin to appear from the second day after the injection and become fully visible after about one week. Their duration is on average five to six months. A follow-up consultation, possibly accompanied by a touch-up, is scheduled between one and three weeks after the session. The after-effects are generally mild, with occasional slight transient swelling lasting a few minutes and mild headaches that may persist for up to five days.
The result of the hyaluronic acid injection is immediate and lasts for one year.
The after-effects are minimal, allowing the patient to resume daily activities immediately after the injection.

What is the cost of an injection for the frown line ?

In Geneva, the price of a botulinum toxin injection to treat frown lines is CHF 300 for women and CHF 350 for men, CHF 450 for two treatment areas for women and CHF 500 for men, and CHF 600 for three treatment areas for women and CHF 650 for men. If an additional hyaluronic acid injection is required, the cost is CHF 600 per syringe.
The treatment plan is established on an individual basis. During the initial consultation, Dr Romano determines with the patient the most appropriate solution according to their needs, in order to achieve a natural and harmonious result.
Whether the goal is to prevent the appearance of frown lines or to soften already established wrinkles, the objective is to restore a relaxed and open expression to the eyes without freezing the face.
All procedures are performed in a medical environment using certified products.
The price of botulinum toxin injections for the treatment of frown lines in Geneva varies according to the number of treatment areas (the frown line corresponds to one treatment area) and the patient's sex (due to differences in muscle strength between men and women).

For women 

  • 1 area (frown line) : 300 CHF
  • 2 areas : 450 CHF
  • 3 areas : 600 CHF


For men 

  • 1 area (frown line) : 350 CHF
  • 2 areas : 500 CHF
  • 3 areas : 650 CHF

If the wrinkle is too pronounced to disappear completely with botulinum toxin, an additional injection of hyaluronic acid may be suggested to achieve an optimal result. The price of this injection is 600 CHF.

Frequently asked questions about frown lines

How can frown lines be prevented ?

Prevention is the key to reducing the appearance of frown lines. Effective advice.

  • Sunglasses : to avoid squinting in the sun.
  • Application of moisturising creams to maintain skin elasticity.
  • Sun protection.
  • Stop smoking : smoking accelerates skin ageing.
  • Skin care : use skin care products containing antioxidants and anti-ageing active ingredients.

Certain essential and plant oils can help reduce the appearance of frown lines thanks to their moisturising and regenerative properties.

  • Rosehip oil : rich in essential fatty acids and vitamin A, it helps to regenerate the skin and reduce wrinkles.
  • Argan oil : known for its moisturising and antioxidant properties, it helps improve skin elasticity.
  • Frankincense oil : this oil has anti-ageing properties and can help smooth wrinkles.

To treat frown lines, we recommend creams containing the following ingredients :

  • Retinol : stimulates collagen production and accelerates cell renewal.
  • Hyaluronic acid : deeply hydrates the skin and fills in wrinkles.
  • Peptides : help strengthen the skin's structure and stimulate the production of collagen and elastin.
  • Antioxidants : such as vitamins C and E, to protect the skin from damage caused by free radicals.

Gua Sha is a massage technique that uses a specific tool to gently scrape the skin, traditionally used in Chinese traditional medicine. Its goal is to improve blood circulation and promote lymphatic drainage.
Regarding the frown line, the regular use of Gua Sha could potentially have beneficial effects.
Results vary from person to person, and Gua Sha does not provide the same results as medical treatments.

The frown line can begin to appear in the late twenties or early thirties, but it generally becomes more pronounced with age, particularly after the age of forty. Genetic factors, sun exposure and smoking influence the age at which this wrinkle appears.

The results of botulinum toxin injections on the frown line appear three to five days after the injection, with a maximal effect visible after about one week. The effects generally last between three and six months, and maintenance sessions are necessary to preserve the results.

Botulinum toxin injections are generally well tolerated and only slightly uncomfortable. The sensation is often compared to a mild insect bite. A topical anesthetic can be applied before the procedure.

Anti-wrinkle creams help improve the appearance of the skin by increasing hydration and stimulating the production of collagen and elastin. However, they cannot relax the muscles responsible for the frown line. For significant results, creams must be combined with botulinum toxin or hyaluronic acid injections.

Facial gymnastics help strengthen facial muscles, improve blood circulation and reduce the appearance of wrinkles. For optimum results, it is advisable to combine these exercises with a good moisturising and skincare routine.

Frown lines are found between the eyebrows on the forehead. These wrinkles are often vertical.

Other areas to be treated