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WHAT TREATMENTS ARE AVAILABLE TO SOFTEN FROWN LINES ?

Last updated : 12 June 2026

A frown line is a vertical crease — sometimes double or triple — between the eyebrows. It develops through repeated contraction of the corrugator and procerus muscles responsible for frowning. Initially visible during facial expressions (concentration, annoyance, stress), it gradually becomes permanent, even at rest, giving the face a stern, tired or worried appearance.
Softening this wrinkle requires understanding its dual nature : both dynamic (muscular) and static (cutaneous). Several options are currently available according to wrinkle depth, the patient's age, muscle tone and skin quality.
The reference treatment for frown lines is botulinum toxin injections, which relax the muscles responsible for their formation and effectively soften folds in the glabella.

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Botulinum toxin to soften frown lines

Among all methods, botulinum toxin injections are the first-choice treatment for softening frown lines. Their effectiveness relies on a precise mechanism : the toxin temporarily inhibits acetylcholine release at neuromuscular junctions, causing targeted relaxation of the muscles responsible for frowning.
By neutralising corrugator and procerus muscle activity, botulinum toxin allows the skin to smooth. Effects generally appear within 3 to 5 days, with optimal results after 10 to 14 days. They last between 4 and 6 months, depending on the patient.
This treatment is particularly recommended for dynamic wrinkles primarily caused by muscle contraction. It is also used preventively in younger patients to stop the wrinkle becoming established.

Botulinum toxin to prevent frown lines

Beyond aesthetic correction, botulinum toxin has a preventive role when injected in younger patients, generally aged between 25 and 35, to treat lines visible during frowning. In these patients, repeated frowning is beginning to change the skin, although the wrinkle is not yet visible at rest.
Low-dose injections partially relax the corrugator muscles without freezing the eyes or changing expression. This preventive treatment, often called “baby botulinum toxin”, significantly delays wrinkle development. It is particularly popular in modern aesthetic medical approaches focused on prevention rather than correction.

Hyaluronic acid to fill frown lines

Once a frown line becomes static, meaning visible even without movement, blocking muscle activity with botulinum toxin injections is no longer sufficient. Hyaluronic acid injections may then be considered to fill the dermal crease and improve skin quality.
This treatment involves injecting a gel of varying fluidity according to wrinkle depth. It must be performed with extreme caution because the glabella is an anatomically high-risk, richly vascularised area. An experienced doctor must therefore establish the indication.
In most cases, hyaluronic acid complements botulinum toxin once muscle activity has been partially or completely neutralised.

Skinboosters to improve frown lines

For patients with a mild frown line but dehydrated skin, Skinboosters may be beneficial. This involves injecting very lightly cross-linked hyaluronic acid in a layering pattern within the middle dermis to restore skin hydration, improve elasticity and stimulate collagen production.
This treatment neither directly erases frown lines nor acts on muscle contraction. However, it improves skin quality in the area and usefully complements botulinum toxin injections. It is often offered as maintenance between botulinum toxin sessions to optimise skin quality and limit new creases.

Fractional lasers and radiofrequency for treating frown lines

In some cases, particularly in patients with a pronounced frown line alongside signs of overall photoageing, skin regeneration techniques may be offered as complementary treatments. Fractional lasers or fractional radiofrequency stimulate collagen synthesis and reorganisation of dermal fibres.
These treatments do not aim to paralyse muscles or fill a crease, but to strengthen the weakened dermal structure, smooth the skin surface and reduce wrinkle depth. Their effectiveness on frown lines remains partial, but is significant when they form part of a combined treatment plan.
They require several sessions spaced a few weeks apart and deliver gradual results over several months. Their indication must be carefully assessed, particularly according to skin phototype and tolerance.

Anti-wrinkle creams 

Although widely used, anti-wrinkle creams cannot erase frown lines alone. Their action is strictly superficial, limited to the epidermis. Even the most effective ingredients (retinol, peptides, hyaluronic acid, niacinamide) cannot reach the muscle or fill deep creases.
However, they can support maintenance : preserving good hydration, strengthening the skin barrier, improving suppleness and prolonging medical treatment effects. They are useful preventively or as complementary care, but are not a therapeutic alternative to injections.

Risks of poorly performed frown line treatment

Although the treatments described can effectively soften frown lines, the risks of suboptimal care are equally important. Poorly performed botulinum toxin injections can cause eyebrow drooping, a frozen expression or facial asymmetry. Similarly, inadequately controlled hyaluronic acid injections into the glabella can create unattractive prominence or, more seriously, vascular occlusion causing skin necrosis or exceptional ocular complications such as blindness.
Although rare, these complications demand the utmost care in choosing a doctor : only an experienced doctor can ensure an aesthetic, lasting and safe result. Frown line treatment must always be regarded as a medical procedure rather than a minor cosmetic service.

Dr Valeria Romano

Article written by Dr Valeria Romano

Dr Valeria Romano supports each patient with a comprehensive approach to the aesthetics of the face, body and intimate areas, and to skin and hair quality. Every treatment is based on a personalised medical assessment.

Learn more about Dr Valeria Romano
Contact Dr Valeria Romano : +41 78 209 02 89 dr.romano.valeria@gmail.com

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