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WHAT ARE THE RISKS OF BOTULINUM TOXIN ?

Last updated : 4 June 2026

Botulinum toxin injections are now widely used to smooth certain expression lines and treat primary excessive underarm sweating.
When performed in a proper medical setting by an experienced doctor in Switzerland, these injections are safe, precise and reversible in their results. However, like any medical procedure, they may sometimes cause side effects. These reactions are overwhelmingly transient and benign, but knowing about them is important.

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Common, harmless side effects after a botulinum toxin injection

Certain side effects are common, expected and disappear spontaneously in the hours or days after injection. They are associated with needle penetration into the skin, individual patient sensitivity or the tissues' natural reaction.

  • Redness at the injection site : small red areas may appear immediately after the session, particularly where skin is thin, such as the eye contour or forehead. They generally disappear in less than an hour.
  • Slight tightness : a feeling of slight tension in the injected area is sometimes reported. It is transient and associated with the product's action on the muscle. This sensation fades spontaneously after a few days.
  • Localised oedema : slight swelling may occur at injection points, particularly if the patient is prone to inflammatory reactions. This phenomenon is temporary and without consequences.
  • Ecchymoses (bruises) : a small blood vessel may occasionally be touched during injection, causing a bruise. It disappears within a few days and can be concealed with appropriate make-up from the following day.

Moderate side effects of botulinum toxin

Some side effects are less common, but well documented and manageable when promptly addressed by an experienced doctor.

  • Temporary facial asymmetry : in rare cases, slight asymmetry may appear if the product distributes unevenly or one muscle responds differently from the other. This resolves spontaneously or through a medical touch-up two to three weeks after injection.
  • Transient eyebrow or eyelid drooping (ptosis) : this rare side effect is associated with product diffusion towards an untargeted muscle. When it occurs, it involves slight eyebrow drooping or, more rarely, the upper eyelid, creating slightly asymmetrical eyes. This reaction disappears spontaneously within a few weeks. It can be avoided through a precise injection technique adapted to the patient's anatomy.
  • Slight limitation of certain expressions : during initial injections, some patients perceive a temporary reduction in facial expressiveness, particularly on the forehead. This can initially be unsettling, but most adapt quickly. Appropriate dosage preserves natural expressions while reducing wrinkles.

Exceptional complications of botulinum toxin

When performed by an untrained doctor or outside an appropriate medical setting, botulinum toxin injections may carry greater risks. Consulting a qualified, experienced doctor is therefore essential.

  • Infection at the injection site : every injection carries an infection risk, even if theoretical. This is extremely rare when performed in a practice strictly complying with aseptic rules. Local infection may present as persistent redness, warmth or unusual pain. It then requires prompt medical care.
  • Product allergy : allergic reactions to botulinum toxin are exceptional but possible. They concern not the toxin itself but albumin, an egg-derived protein used as a carrier. An allergy may cause itching, a rash or more pronounced oedema. The doctor systematically checks for an absence of allergic history at the first consultation.
  • Resistance to botulinum toxin : in very rare cases, a patient may develop partial or total resistance to the product. This generally occurs after many injections spaced too closely together. It can be addressed by adjusting the protocol or using another formulation.

How can side effects of botulinum toxin on the face be prevented ?

Preventing botulinum toxin side effects relies above all on a rigorous medical protocol. It begins with choosing an experienced doctor specifically trained in facial injections. A complete prior discussion is essential to assess muscle dynamics, natural asymmetries, medical history and patient expectations. Precise injection technique adapted to each patient's anatomy is also decisive. Following post-treatment instructions contributes to result quality and avoids side effects. Finally, the patient must report any neuromuscular condition, ongoing treatment or possible pregnancy so the doctor can adjust the protocol or postpone the session if necessary.

Is botulinum toxin a safe long-term facial treatment ?

Botulinum toxin is a safe, well-tolerated long-term treatment when appropriately used. Clinical studies conducted for more than thirty years have identified no harmful effects on muscles or skin. Conversely, patients continuing regular treatments often observe visibly slower skin ageing, gradually improved skin quality and a natural reduction in muscular strength in treated areas. However, appropriate treatment frequency is essential. Most patients benefit from two to three sessions a year according to physiology and aesthetic objectives.

Conclusion : risks of botulinum toxin injections

Botulinum toxin injections are now among aesthetic medicine's safest and best-mastered procedures. The vast majority of side effects are mild and transient, easily managed when treatment is performed in a rigorous medical setting. Serious complications are exceptional and can be avoided through precise diagnosis, fully mastered injection technique and attentive follow-up. To ensure a natural, safe result, consulting an experienced doctor in Geneva who can adapt treatment to each patient's morphology and expectations is essential.

Dr Valeria Romano

Article written by Dr Valeria Romano

Dr Valeria Romano supports each patient with a comprehensive approach to the aesthetics of the face, body and intimate areas, and to skin and hair quality. Every treatment is based on a personalised medical assessment.

Learn more about Dr Valeria Romano
Contact Dr Valeria Romano : +41 78 209 02 89 dr.romano.valeria@gmail.com

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