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WHAT ARE THE BENEFITS OF HYALURONIC ACID FOR FILLING NASOLABIAL FOLDS ?

Dernière mise à jour : 3 July 2026

Among the earliest signs of facial ageing, nasolabial folds occupy a particular place. Visible from their thirties in some patients, they gradually become deeper and more pronounced with age, often giving the face a tired or harsh appearance. To correct these folds and restore lower-face harmony, hyaluronic acid injections are now the reference solution, combining effectiveness, safety and adaptability.
But from a strictly medical and aesthetic perspective, what are the benefits of hyaluronic acid when used to treat nasolabial folds ? What are its specific properties ? Why has this product become essential in managing this indication ? This article aims to answer these questions using literature data, clinical experience and the physiological foundations of facial ageing.

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Why is hyaluronic acid effective for nasolabial folds ?

Hyaluronic acid is a molecule naturally present in the dermal extracellular matrix. Composed of a disaccharide polymer, it has an exceptional capacity to retain water, up to a thousand times its weight, making it a key contributor to skin hydration, tissue suppleness and dermal tone.
Injected as a cross-linked gel, hyaluronic acid acts not only as a volumiser, but also as a support and skin-stimulating agent. It integrates harmoniously into tissues, respects facial dynamics and adapts to the treated area. For nasolabial folds, whose depth results from a dual mechanism (vertical laxity and loss of support), it offers a tailored structural response.

How does hyaluronic acid fill nasolabial folds ?

Hyaluronic acid is particularly effective for nasolabial folds because it restores lost volume. Injected deeply, it restores cheekbone fullness, supports lax tissues and mechanically reduces fold depth.
This three-dimensional approach rebalances volume in the middle and lower thirds of the face, creating a more harmonious, naturally rested appearance. Unlike treatments acting only on the surface, hyaluronic acid directly targets the fold's cause by filling the space left by fat loss and lax supporting structures.

What are the advantages of hyaluronic acid for nasolabial folds ?

One specific advantage of hyaluronic acid is its excellent malleability, allowing the doctor to adjust injected volumes precisely to the patient's anatomy, area mobility, skin quality and desired result. This personalisation produces a visible yet subtle effect respecting facial identity.
Furthermore, hyaluronic acid is biodegradable and reversible. . This provides unrivalled treatment flexibility and reassures patients concerned about permanent effects.
Finally, latest-generation gels, such as those using Vycross®, RHA® or OBT® technology, show remarkable tissue integration, with little migration, even integration and excellent long-term tolerance.

Does hyaluronic acid improve skin quality ?

Beyond its strictly volumising effect, hyaluronic acid injected into nasolabial folds offers a secondary benefit for skin quality. Several studies have shown that injection indirectly stimulates type I collagen synthesis, improves local vascularisation and reactivates fibroblast activity.
These effects produce more supple, denser, better-hydrated skin and gradually reduce the small dermal creases that visually accentuate the nasolabial fold. This benefit is particularly noticeable in patients with thin, lax or photoaged skin.
Treatment therefore does more than fill a hollow : it revitalises the injected area, improves skin and, to a certain extent, prevents the fold from worsening.

Why choose hyaluronic acid injections for nasolabial folds ?

Another significant benefit is that hyaluronic acid correction of nasolabial folds is an outpatient procedure that is quick, minimally painful and requires no social downtime. Performed in medical practice, injection takes a few minutes.
Activities can resume immediately. Side effects, when present, are temporary : slight swelling, localised bruising and a feeling of tension. In most cases, they resolve within 48 to 72 hours.
This accessibility largely explains the method's success, particularly among active patients wishing to improve their appearance without invasive procedures or surgery.

Why treat nasolabial folds as part of an overall facial approach ?

Hyaluronic acid treatment of nasolabial folds forms part of an overall approach to facial rejuvenation. It aims to restore balance between facial volume, curves and highlights rather than simply erase a fold. When performed well, it can be combined with complementary interventions : restoring cheekbone volume, treating dark circles or marionette lines, or redefining the jawline.
The doctor must therefore have a consistent understanding of facial structure and avoid isolated corrections that could create imbalance. In this approach, hyaluronic acid becomes a tool for facial harmonisation rather than a simple anti-wrinkle solution.

How long do the effects of hyaluronic acid on nasolabial folds last ?

An often overlooked advantage of hyaluronic acid is the durability of its results. When injected precisely into nasolabial folds, an appropriate product can remain effective for nine to fifteen months. This depends on the patient's metabolism, gel type and surrounding tissue characteristics.
To maintain facial harmony, regular maintenance, generally once or twice a year, is recommended. Each session allows treatment to be adjusted to changing features, patient expectations and clinical observations. This gradual, tailored approach accompanies ageing gently while respecting each face's identity and individuality.

What are the psychological benefits of nasolabial fold treatment ?

Beyond purely structural benefits, the positive psychological impact of nasolabial fold correction should not be overlooked. When highly pronounced, this fold can convey an unfelt emotion (sadness, fatigue, harshness), creating a mismatch between perceived identity and outward appearance.
By softening this mismatch, hyaluronic acid restores consistency between appearance and inner feelings, directly affecting self-confidence and social image. Patients often express these benefits spontaneously, and they are integral to treatment success.

Can hyaluronic acid prevent nasolabial folds from worsening ?

Hyaluronic acid is not only corrective, but can also play a preventive role in nasolabial fold development. Injected subtly at the first signs of hollowing, it helps maintain tissue hydration and support, slows weakening of supporting fibres and prevents gradual creasing of the deep dermis.
This preventive approach, sometimes called « maintenance medicine », is particularly suited to younger patients, generally between 30 and 40, when skin begins losing tone. It offers a subtle yet gradual anti-ageing effect that accumulates over time to preserve facial freshness and balance.

Dr Valeria Romano

Article written by Dr Valeria Romano

Dr Valeria Romano supports each patient through a comprehensive approach to facial, body and intimate aesthetics, as well as skin and hair quality. Every treatment is based on a personalised medical assessment.

Learn more about Dr Valeria Romano
Contact Dr Valeria Romano : +41 78 209 02 89 dr.romano.valeria@gmail.com

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