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BOTULINUM TOXIN FOR EXPRESSION LINES : IS IT EFFECTIVE ?

Last updated : 7 July 2026

Botulinum toxin is effective for treating expression lines in the upper facial third.
Expression lines — folds appearing with facial movements — are often the first visible signs of skin ageing. Whether frowning, smiling, squinting or raising eyebrows, these repeated gestures eventually mark skin permanently over the years.
Botulinum toxin is now the reference treatment for reducing these dynamic wrinkles. Used in aesthetic medicine for more than twenty years, it relaxes muscles responsible for repeated contractions.
But how exactly does it work ? What results can it achieve ? In which situations is it most indicated ? Here are the essential points to know.

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What are “expression lines” ?

Expression lines, or dynamic wrinkles, appear from repeated facial muscle contraction. Unlike static wrinkles (associated with skin laxity or volume loss), they form in precise areas directly linked to everyday expressions. Fine horizontal lines gradually mark the forehead through repeated eyebrow elevation : forehead lines. Between the eyebrows, the glabella develops the familiar frown line. The eye contour creases over time through smiling or repeated blinking, producing crow's feet.
Initially, these wrinkles are visible only during expressions. Over the years, they become etched into the skin and visible even when the face is relaxed.

Botulinum toxin : treatment for wrinkles

Botulinum toxin acts directly on the muscle responsible for the wrinkle by temporarily blocking the nerve transmission commanding contraction. In other words, it partially or completely rests the muscle, allowing overlying skin to relax and smooth.
Unlike hyaluronic acid, which fills, botulinum toxin adds no volume. It alters neither features nor facial structure. It acts from within by removing the wrinkle's mechanical cause.
This mechanism makes it the most effective treatment to prevent expression lines from becoming established (Baby botulinum toxin), reduce existing wrinkles and soften features without altering facial identity.

Botulinum toxin : proven effectiveness

Results are generally noticeable between the third and seventh day after injection. The effect then stabilises within approximately fifteen days. Skin looks smoother and more rested, and the face relaxed and less marked. By limiting repeated contractions, botulinum toxin also helps prevent new wrinkles.
Treatment effectiveness depends on factors such as facial muscle strength, skin quality, selected dosage and procedural precision. On average, effects last between four and six months. The muscle then gradually resumes activity. A maintenance session prolongs results harmoniously and naturally.

Which expression lines respond best to botulinum toxin

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Botulinum toxin targets certain wrinkles associated with repeated facial expressions. It is particularly effective for smoothing horizontal dynamic forehead lines, frown lines between the eyebrows and crow's feet at eye corners. 
Precisely injected botulinum toxin relaxes the areas concerned without freezing the face, which remains expressive, natural and simply calmer.
Botulinum toxin is also indicated for primary axillary hyperhidrosis. 

Can an expression line be completely erased ?

Its effect depends above all on wrinkle depth at treatment time. When a wrinkle remains dynamic, visible only during expressions, it may disappear completely after injection. If already marked at rest, treatment noticeably reduces it but a slight fine line may persist, particularly on thin skin.
In this case, botulinum toxin can be combined with Skinbooster injections. This further improves skin quality and smooths the wrinkle while preserving the muscular relaxation achieved with botulinum toxin.

Is botulinum toxin effective preventively ?

Botulinum toxin can also be used preventively. Administered at low doses in young patients, it helps prevent static wrinkles by limiting muscular hyperactivity. This approach, often called Baby botulinum toxin, aims to preserve skin quality while retaining a natural appearance.
It is particularly indicated in highly expressive people, those whose skin marks easily or within a comprehensive ageing-prevention strategy. This gentle, gradual approach maintains a relaxed, harmonious face without altering features.

Conclusion : botulinum toxin and expression lines

Botulinum toxin is the reference treatment for smoothing expression lines. Its action is precise, measured and lasting while respecting natural facial harmony. Appropriately injected, it softens rather than alters features. The face looks more rested, less marked by severity, tension or fatigue and retains expressiveness.
Botulinum toxin's strength lies in targeted, reversible and adjustable action. This makes it, to date, the most effective and refined solution for dynamic wrinkles.

Dr Valeria Romano

Article written by Dr Valeria Romano

Dr Valeria Romano supports each patient with a comprehensive approach to the aesthetics of the face, body and intimate areas, and to skin and hair quality. Every treatment is based on a personalised medical assessment.

Learn more about Dr Valeria Romano
Contact Dr Valeria Romano : +41 78 209 02 89 dr.romano.valeria@gmail.com

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