FAILED NASOLABIAL FOLD INJECTION

Hyaluronic acid nasolabial fold Geneva

The injection of hyaluronic acid into the nasolabial folds is a common procedure aimed at softening the signs of aging and restoring a gentler, more relaxed facial expression. However, despite the minimally invasive nature of the treatment, some injections may prove unsatisfactory or even lead to temporary or longer-lasting side effects. A “failed” nasolabial fold injection is the result of an inappropriate product choice, an incorrect indication, or a poor injection technique.
Understanding the causes and manifestations of an improper correction is essential for both the physician and the patient, in order to identify the most appropriate solution : correction, monitoring, or, in some cases, product dissolution.

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Hyaluronic acid injection in the nasolabial folds

The nasolabial folds are areas that are both mobile and anatomically complex. They result from sagging of the midface tissues and a loss of bony and fatty support. Their treatment is not simply about “filling a wrinkle,” but about restoring volume harmony.
Poor consideration of this anatomical reality can lead to an unsatisfactory result, even if the technical gesture appears well executed. It is therefore crucial to distinguish between errors in product selection, technical mistakes, and temporary side effects.

Failed injection : which signs should raise concern ?

A poorly performed or unsuitable injection may manifest through several types of undesirable outcomes, ranging from minor aesthetic discomfort to more serious complications. The main signs of a “failed” injection are :

Unesthetic or unnatural result :

  • Overcorrection : the fold appears excessively filled, forming a visible bulge, especially at rest.
  • Asymmetry : one side of the face appears fuller or more hollow than the other, disrupting the balance of the smile or the overall facial harmony.
  • Frozen facial expression : the product is too dense or injected too superficially, causing visible stiffness during facial movements.
  • Product migration : the hyaluronic acid moves slightly outside the fold, creating a palpable or visible irregularity.


Abnormal sensations or discomfort :

  • Localized induration : small lumps under the skin, often caused by poor tissue integration or a cluster of product.
  • Painful tension : the patient feels constant discomfort, sometimes worsened during facial expressions.
  • Persistent swelling : prolonged puffiness beyond 7 to 10 days, which may indicate fluid retention or local inflammation.


Rare but more serious complications :

  • Bluish discoloration (Tyndall effect) : occurs when the product has been injected too superficially, especially in cases of thin skin.
  • Infection or inflammatory granuloma : persistent redness, pain, localized warmth, or inflammatory nodules require specific medical management.
  • Vascular complication : extremely rare but serious, it can occur if the hyaluronic acid compresses or blocks a blood vessel. It manifests as sudden pain, skin blanching, and, if left untreated, cutaneous necrosis.

Why can an injection fail ?

Although hyaluronic acid is widely used for its quick and natural results, some injections may not achieve the expected effect. Several factors related to the product, the technique, or the patient can explain these failures.

  • Inappropriate choice of hyaluronic acid : using a gel that is too dense or insufficiently cohesive in a mobile area such as the nasolabial fold can lead to a rigid result, noticeable visually or to the touch. Conversely, a product that is too fluid in a deep fold will not be sufficient to achieve a satisfactory result. Some products are specifically designed for this area. But using these volumizing hyaluronic acids in a superficial fold or on thin skin may induce an excessive or unaesthetic correction.
  • Inappropriate injection technique : mastering the injection plane (subcutaneous, pre-periosteal, intradermal) is essential. An injection that is too superficial increases the risk of the Tyndall effect, while one that is too deep may fail to produce results. The cannula is often preferred for its safety and consistency, but it requires good manual skill.
  • Incorrect indication or incomplete analysis : sometimes, the nasolabial fold is treated in isolation, even though its appearance is secondary to volume loss in the cheeks or temples. Injecting the fold without restoring the upper third of the face — through filling techniques or medical lifting — is an inadequate approach that does not address the root cause of the problem.

What solutions are available in case of a failed injection ?

When a hyaluronic acid injection does not deliver the expected result, there are fortunately several options to correct or improve the situation. Everything depends on the nature of the problem.

  • Observation and monitoring : in some cases, side effects are temporary. Swelling, mild asymmetry, or induration resolve spontaneously within two to three weeks. Careful medical follow-up is therefore essential.
  • Massage or localized correction : gentle massages can help promote product integration. In some cases, a small targeted touch-up or the dissolution of excess product can help balance the result.

How to avoid a failed injection ?

The physician’s experience plays a central role in the quality of the result. A perfect understanding of facial anatomy, combined with a personalized analytical approach, allows each injection to be adapted to the patient’s morphology and expectations. This expertise ensures a natural, harmonious, and long-lasting result, without overcorrection or stiffness of expression.
The success of the treatment also relies on collaboration between the patient and the physician. It is essential that the patient :

  • Clearly expresses their aesthetic expectations in order to define a realistic and appropriate goal.

  • Reports any medical history or ongoing treatment to ensure the safety of the injection.

  • Understands that the purpose of the filling is not to completely erase the folds or freeze facial features, but to restore a balanced and natural facial dynamic.

Finally, the use of high-quality hyaluronic acids, selected according to skin type, fold depth, and tissue mobility, is a key factor for success. Combined with a well-mastered technique, this standard ensures a reliable, discreet, and long-lasting result. In Geneva, consulting an experienced physician thus guarantees patients a safe treatment and results that meet their expectations.

Can a reinjection be performed after a failed injection ? 

A failed injection of the nasolabial fold does not exclude the possibility of a successful later correction. A reinjection may be considered, but only under certain conditions. It is essential that the initial product has had time to partially or completely resorb. It is also necessary to wait for the complete disappearance of any local reaction, whether it is inflammation or edema. Finally, the causes of the failure must be precisely analyzed, whether it is an inappropriate product choice, a technical error, or a poorly chosen injection plan. When retreatment is possible, it must be entrusted to an experienced physician.

Responsibility of the physician in case of an unsatisfactory result 

While most failed injections stem from technical errors or poor procedural choices, some situations are linked to post-treatment behaviors that compromise the result. These include excessive massage of the injected area, exposure to heat (sauna, steam room, intense exercise) within 48 hours, use of anticoagulant or anti-inflammatory medications not disclosed to the injecting physician beforehand, lack of follow-up, or failure to follow medical instructions.
The patient’s active involvement in adhering to post-injection guidelines is an essential condition for the success and longevity of the treatment.

Failed injection by a non-physician : what are the possible remedies ?

Unfortunately, some failed nasolabial fold injections occur after procedures performed by unauthorized individuals, beauticians, self-injections, or unqualified practitioners operating in countries with more permissive regulations. These situations expose patients to multiple dangers, such as the use of non-compliant products, poor hygiene conditions, or increased risks of infection, necrosis, and even irreversible damage. In Switzerland, only physicians trained in aesthetic-oriented medicine are authorized to perform hyaluronic acid injections. In the event of harm, medical and legal recourse can be sought through the competent health authorities.

Photo of doctor Valeria Romano in Geneva

Article written by Dr Romano Valeria

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